Bravecto ® Plus . As I opened the packaging I split some on my hands. 0061-5996-01, For cats, Bravecto® flea treatment is available as a topical solution, which is applied to your catâs skin on the back of their neck. If a second spot is needed to avoid run off, then apply the second spot slightly behind the first spot. Bravecto Plus Spot-on Solution for Cats is for cats with, or at risk from, mixed parasitic infestations by ticks and fleas, gastrointestinal nematodes or heartworm. The chemical name of fluralaner is (±)-4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)- 4,5-dihydroisoxazol-3-yl]-2-methyl-N-[2-oxo-2-(2,2,2- trifluoroethylamino)ethyl]benzamide. RxNorm, If a dose is missed and a 2-month interval between doses is exceeded, administer Bravecto Plus immediately and resume the dosing every 2 months. Bravecto Plus was not effective when administered more than 2 months prior to infection. Moxidectin is for systemic use and is a semisynthetic derivative of nemadectin, belonging to the milbemycin group of macrocyclic lactones. If contact with eyes occurs, then flush eyes slowly and gently with water. Step 2: your cat should be in a standing position or lying down with a straight, horizontal back position is also fine. Reg. How to apply BRAVECTO Topical Solution for Cats A single dose should be applied to the skin on the back of the neck (separate fur if needed) with the easy Twist'n'Use ⢠applicator once every 12 weeks. For topical use only. Doses of BRAVECTO® for dogs and BRAVECTO® for cats are counted separately and cannot be added together when determining rebate amounts. Safety in cats infected with adult heartworm (Dirofilaria immitis): Bravecto Plus was administered topically to cats infected with adult heartworm at 1X or 3X the maximum labeled dose of 93.0 mg fluralaner/kg and 4.7 mg moxidectin/kg (8 cats per group). Step 3: Squeeze the tube and gently apply the entire contents of Bravecto Plus directly to the skin at the base of the skull of the cat. This class has been associated with neurologic adverse reactions including tremors, ataxia, and seizures. DailyMed will deliver this notification to your desktop, Web browser, or e-mail depending on the RSS Reader you select to use. To report suspected adverse events, for technical assistance or to obtain a copy of the Safety Data Sheet (SDS), contact Merck Animal Health at 1-800-224-5318. There were no clinically-relevant, treatment-related effects on physical examination, body weights, food consumption, clinical pathology (hematology, clinical chemistries, coagulation tests, serum amyloid A, and urinalysis), gross pathology, histopathology, or organ weights. Keep the product in the original packaging until use in order to prevent children from getting direct access to the product. The tube is open and ready for application when a breaking of the seal is felt. BRAVECTO PLUS has not been shown to be effective for 2 months in kittens less than 6 months of age. 3 doses of BRAVECTO® per pet, get a rebate of $20; 4 doses of BRAVECTO® per pet, get a rebate of $30. Bravecto Plus is indicated for the prevention of heartworm disease caused by Dirofilaria immitis and for the treatment of infections with intestinal roundworm (Toxocara cati; 4th stage larvae, immature adults and adults) and hookworm (Ancylostoma tubaeforme; 4th stage larvae, immature adults and adults). Fleas are killed in up to 12 hours after treatment or after reinfestation during the 3 month treatment period. Field Safety Study: In a well-controlled field study, Bravecto Plus was used concurrently with other medications, such as vaccines, anthelmintics, antibiotics and steroids. This solution seeps into the tissues located beneath the skin, and when fleas and ticks bite, they ingest the solution and die within 8 hours. Copyright © 2021 Animalytix LLC. The effectiveness of Bravecto Plus to prevent heartworm disease after bathing or water immersion has not been evaluated. The product is highly flammable. Each milliliter contains 280 mg of fluralaner and 14 mg of moxidectin. Discount flea, tick, heartworm and intestinal worm treatments by PetBucket. A veterinarian or veterinary technician should demonstrate or instruct the pet owner regarding the appropriate technique for applying Bravecto Plus topically to cats prior to first use. 0061-5997-01, Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Each tube is packaged individually in a pouch. BRAVECTO® PLUS . Compared to other products which must be given every month. Compare. Peak fluralaner concentrations are achieved between 3 and 21 days following topical administration and the elimination half-life ranges between 11 and 18 days. Bravecto® Spot On for Cats is a topical solution that is applied to your catâs skin on the back of their neck. Bravecto Plus (fluralaner and moxidectin topical solution) for Cats. One cat within 4 hours of use developed ataxia involving loss of use of back legs, head tremor and has had to go into the Vet for overnight observation in case she developed fits. Step 2: The cat should be standing or lying with its back horizontal during application. Apply at the base of the skull, to ensure wet product can't be licked. BRAVECTO PLUS is an extended-duration, broad-spectrum combination (fluralaner and moxidectin) topical solution for cats, indicated for both external ⦠After applying Bravecto for Cats, the medication quickly reaches tissue fluids under your cat's skin. Caution: Federal (USA) law restricts this drug to use by or on the order of a licensed veterinarian. Avoid oral ingestion. In well-controlled laboratory studies, Bravecto Plus demonstrated ≥ 98.1% effectiveness against Ixodes scapularis 48 hours after treatment or infestation for 2 months. The seal was broken on the first pack of Bravecto Plus for cats I purchased. Treated kittens had reduced food consumption on the day of treatment. These cats also had mild elevations of aspartate aminotransferase (AST) (less than twice the upper reference range of 100 IU/L). Foreign Market Experience: The following adverse events were reported voluntarily during post-approval use of the product in cats in foreign markets: polydipsia, swelling of chin and lips, periorbital swelling, blepharospasm, pruritus, erythema, aggression, agitation, pyrexia, mydriasis, hypersalivation, hyperactivity, alopecia, and excessive grooming. Caution: Federal (USA) law restricts this drug to use by or on the order of a licensed veterinarian. 0061-5998-02, The cap is designed to stay on the tube for dosing and should not be removed. Five of six treated kittens experienced hypersalivation. It is exclusively indicated when use against ticks or fleas and one or more of the other target parasites is indicated at the same time. Two untreated cats were found dead prior to dosing. Copy the URL below and paste it into your RSS Reader application. View NDC Code(s)NEW! Wash hands and contacted skin thoroughly with soap and water immediately after use of the product. When fleas and ticks feed on your cat, they ingest Bravecto for Cats and die. Part the hair and apply to the skin on the back of the head, as per the diagram. The cats in the control group (0X) received mineral oil topically. (fluralaner and moxidectin topical solution) for Cats. Bravecto Plus is available in three tube sizes to treat cats ranging in weight from 2.6 lb - 27.5 lb (1.2 kg to 12.5 kg). The chemical name of fluralaner is (±)-4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)- 4,5-dihydroisoxazol-3-yl]-2-methyl-N-[2-oxo-2-(2,2,2- trifluoroethylamino) ethyl]benzamide. The kittens in the control group (0×) were treated with mineral oil. BRAVECTO PLUS- fluralaner and moxidectin solution. Not for human use. The mode of action of fluralaner is the antagonism of the ligand-gated chloride channels (gamma-aminobutyric acid (GABA)-receptor and glutamate-receptor). For topical use only. In a European field study for fluralaner topical solution for cats, there were three reports of facial dermatitis in humans after close contact with the application site which occurred within 4 days of application. Peak moxidectin concentrations are achieved between 1 and 5 days following topical administration and the elimination half-life ranges between 20 and 30 days. Fluralaner is a member of the isoxazoline class. The pouch should only be opened immediately prior to use. Contents: 1 tube containing 250 mg fluralaner and 12.5 mg moxidectin Approved by FDA under NADA # 141-518, For cats and kittens 6 months of age and older Advantages NEW BRAVECTO® PLUS (fluralaner and moxidectin topical solution) for Cats is the solution for fleas, ticks, heartworm and intestinal parasites in ONE easy, 2-month topical. Self-limiting hypersalivation due to grooming was observed on the day of treatment in both treatment groups (6/8 cats in the 1X group and 7/8 cats in the 3X group). Hold the tube at the crimped end with the cap in an upright position (tip up). The kittens in the control group were administered saline orally. No. Avoid oral ingestion (see Animal Safety). The cap should be rotated clockwise or counter clockwise one full turn. For Large Cats . When replacing a monthly heartworm preventative product, the first dose of Bravecto Plus should be given within one month of the last dose of the former medication. Bravecto® works by seeping into the tissues located beneath the skin. Bravecto Plus Spot-On is for cats with, or at risk from, mixed parasitic infections by ticks and fleas, gastrointestinal nematodes or heartworm. Show. https://dailymed.nlm.nih.gov/dailymed/labelrss.cfm?setid=d9d5ebde-7ff7-4864-b393-fbe77d7a112f, https://dailymed.nlm.nih.gov/dailymed/rss.cfm. Step 3: Squeeze the tube and gently apply the entire contents of BRAVECTO directly to the skin at the base of the skull of the cat. FOR EXTERNAL ANIMAL USE ONLY . When replacing a monthly heartworm preventative product, the first dose of Bravecto Plus should be given within one month of the last dose of the former medication. Fluralaner is an inhibitor of the arthropod nervous system. Bravecto Plus for Cats is a formulation made up of two active ingredients â Fluralaner and Moxidectin which work together brilliantly in fighting off all parasitic creatures and providing month-long protection. Part the hair and apply directly to the skin. The effectiveness of Bravecto Plus to prevent heartworm disease after bathing or water immersion has not been evaluated. Bravecto Plus has not been shown to be effective in kittens less than 6 months of age. Compare. Due to inconsistencies between the drug labels on DailyMed and the pill images provided by RxImage, we no longer display the RxImage pill images associated with drug labels. Bravecto Plus should be administered topically as a single dose every 2 months according to the Dosage Schedule below to provide a minimum dose of 18.2 mg/lb (40 mg/kg) fluralaner and 0.9 mg/lb (2 mg/kg) moxidectin. Citations, PRINCIPAL DISPLAY PANEL - 112.5 mg/5.6 mg Tube Pouch Carton, PRINCIPAL DISPLAY PANEL - 250 mg/12.5 mg Tube Pouch Carton, PRINCIPAL DISPLAY PANEL - 500 mg/25 mg Tube Pouch Carton, (What Specifically designed for the challenges of treating cats, BRAVECTO PLUS delivers everything that you expect from BRAVECTO and more. Place the tube tip vertically against the skin at the base of the skull of the cat. Use with caution in cats with a history of neurologic disorders. Greasy, oily, or wet appearance may occur at the application site in some cats. To view updated drug label links, paste the RSS feed address (URL) shown below into a RSS reader, or use a browser which supports RSS feeds, such as Safari for Mac OS X. Bravecto Plus spot-on for cats works fast and continues to protect against fleas for 3 months, paralysis ticks for 10 weeks and heartworm for 2 months, plus treats roundworm, hookworm and ear mites. To apply, simply part the hair at the nape of your catâs neck and squeeze out the product from the convenient TwistânâUse⢠applicator onto the exposed skin. In a well-controlled U.S. field study, which included a total of 176 treated cats (135 with Bravecto Plus and 41 with a monthly topical active control), there were no serious adverse reactions. Bravecto Plus may be administered year-round without interruption or at a minimum should be administered at 2-month intervals beginning at the cat's first seasonal exposure to mosquitoes and continuing until the cat's last seasonal exposure to mosquitoes. It treats and prevents ticks, fleas, heartworms, and several kinds of worms. Keep away from heat, sparks, open flame or other sources of ignition. Out of scope information includes radiopharmaceuticals, contrast media, herbals, homeopathics, and food. Each tube is formulated to provide a minimum dose of 18.2 mg/lb (40 mg/kg) fluralaner and 0.9 mg/lb (2 mg/kg) moxidectin. Fluralaner, one of the ingredients in Bravecto Plus, is a member of the isoxazoline class. Each tube is packaged individually in a pouch. In two well-controlled laboratory studies, Bravecto Plus was 100% effective against induced heartworm infections when administered 2 months prior to infection. Hold the tube at the crimped end with the cap in an upright position (tip up). View Labeling Archives, Not for human use. Keep away from heat, sparks, open flame or other sources of ignition. Avoid oral ingestion. Step 3: Squeeze the tube and gently apply the entire contents of Bravecto Plus directly to the skin at the base of the skull of the cat. * Cats over 27.5 lb should be administered the appropriate combination of tubes. If a dose is missed and a 2-month interval between doses is exceeded, administer Bravecto Plus immediately and resume the dosing every 2 months. Additional information can be found at www.bravecto.com. If wearing contact lenses, eyes should be rinsed first, then remove contact lenses and continue rinsing, then seek medical advice immediately. The safety of BRAVECTO has not been established in breeding, pregnant and lactating cats. There were no clinically-relevant, treatment-related effects on physical examination, body weights, food consumption, clinical pathology (hematology, clinical chemistries, coagulation tests, serum amyloid A, and urinalysis), gross pathology, histopathology, or organ weights. published 4 months ago. Peak fluralaner concentrations are achieved between 3 and 21 days following topical administration and the elimination half-life ranges between 11 and 18 days. The kittens in the control group (0X) were treated with mineral oil. Use with caution in cats that are heartworm positive (see Animal Safety). * 3 Cats over 27.5 lb. When fleas and ticks bite, they ingest the solution and die within 8 hours. Avoid contact with skin and eyes. There were no clinically-relevant, treatment-related effects on body weights, clinical pathology (hematology, clinical chemistry, and coagulation profile), gross pathology or histopathology. The chemical name of moxidection is (2aE,4E,5'R,6R,6'S,8E,11R,13S,15S,17aR,20R,20aR,20bS)-6'-[(E)-1,3-Dimethyl-1-butenyl]-5',6,6',7,10,11,14,15,17a,20,20a,20b-dodecahydro-20,20b-dihydroxy-5',6,8,19-tetramethylspiro[11,15-methano-2H,13H,17H-furo[4,3,2-pq][2,6]benzodioxacyclooctadecin-13,2'-[2H]pyran]-4',17(3'H)-dione 4'-(E)-(O-methyloxime). Price $ 49.90 $ 65.00 cats kills fleas, ticks, fleas, heartworms, and to! The cap should be in a standing position or lying down with history! Reported in cats with a simple twist-n-use dispensing tube making it quick and easy to use of for! No longer wish to have this dailymed RSS service, simply delete the copied URL from RSS. This site through its RSS feed, view NDC Code ( s ) New group exhibited depression, dehydration a... 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